Jul 19, 2013

Better Drug Delivery Through Liposome

By Irma Farrell


Scientists have been trying out different delivery methods to increase specificity in drugs. This will make drugs more effective. It calls for a specific design and structure which has favored liposome over other methods used in the past. The advantages have been listed as higher payload, stealth operations, less harmful side effects, reduced circulation time and ability to target specific body areas. These properties describe an effective drug.

Incredible results have been obtained from testing liposomes over the years. They have shown a great deal of potential that scientists seek to utilize. Some of the admirable aspects with liposomes include enzyme resistance during metabolism, high solubility as well as specificity. Researchers are narrowing down on this element.

The structure and design of liposomes make drugs that are encapsulated using the compounds to be easily absorbed in the body. They are flexible making it easier to control release of important elements in the body. There is reduced toxicity because lower dosages are administered. This means that side effects are reduced. It is the preferred mode of delivering gene therapy drugs.

There is an effect when one considers the sizes of liposomes required to deliver the drugs. This translates into reliable efficacy considering that circulation in the blood and residence are enhanced. Target drugs are easily absorbed by body organs and their efficacy enhanced. This has a bearing on the effectiveness of the drug. Getting a specific size is the current focus in most of the studies to boost effectiveness.

Getting an expert in solution development and manufacture depends on experience and dedication. You will get a solution that is customized for the project at hand. There are a variety of lipid and liposomal solutions provided for the market. Other solvents and surfactants are used in optimizing existing solutions.

The processes used in developing the solutions vary between scalable, batched and semi-continuous. Experience and uses of the latest manufacture processes and equipment ensures that the solutions are accurate and effective. They can be scaled to industrial quantities. The processes that will benefit clients include sizing and preparation through extrusion and high-pressure homogenization. Purification is done by filtration using sterilization and tangential flows.

There is a package for such processes as solvent injection, lipid hydration, aseptic processes as well as lyophilization. Liposomal analysis is carried out to determine particle distribution and sizes. Related procedures include electron microscopy, encapsulation efficiency testing and determination of zeta potential. Drug loading is offered in this package.

A customized solution is what each client should get from any reliable firm. The firm should offer diverse products that are in line with market demands. Having the same developer manufacture your products is recommended. There are reduced chances of variations or errors in composition.

The inability of enzymes to detect liposome has endeared it to drug manufacturers. It has responded well on specificity and meets the expectations by developers. This is a dependable element in reducing body toxicity through specific target. This has been achieved through expert design and structuring.




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